Anti-ZBTB33 Polyclonal Antibody

品牌：solarbio | 货号：K002695P

商品货号：	商品品牌：	规格	基本售价：	选择规格
K002695P-50ul	solarbio	50ul	960.00元
K002695P-100ul	solarbio	100ul	1600.00元

英文名称	Anti-ZBTB33 Polyclonal Antibody
别名	ZNF-kaiso;ZNF348
应用	WB
稀释比例	WB 1:1000-3000.
交叉反应	Human Mouse
蛋白分子量	74kDa
Gene ID	10009
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	Recombinant protein of human ZBTB33
性状	液体
Public Immunogen Range	Recombinant protein of human ZBTB33
Subcellular Locations	Cytoplasm Nucleus
Swiss Prot	Q86T24
克隆类型	Polyclonal Antibody
背景资料	This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.